Dichloromethane → 1-Bromo-3-(bromomethyl)-5-chlorobenzene

HRID 917540ノート

反応式

HRID 917540 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH3:9])[CH:5]=[C:6]([Cl:8])[CH:7]=1.C1C(=O)N([Br:17])C(=O)C1.CC(N=NC(C#N)(C)C)(C#N)C.ClCCl>C(Cl)(Cl)(Cl)Cl>[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([CH2:9][Br:17])[CH:3]=1

参加物

6

反応物 4

HCID 6344DichloromethaneHCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 107746383-Bromo-5-chlorotoluene

生成物 1

HCID 223242641-Bromo-3-(bromomethyl)-5-chlorobenzene

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

反応条件

温度
80 °C

実験手順

Step G2. The mixture of 3-bromo-5-chlorotoluene (9 g, 43.8 mmol), NBS (8.19 g, 46 mmol), and AIBN (200 mg) in carbon tetrachloride (50 mL) was heated at 80° C. for 3 hours. The resulting mixture was run through a silicon gel column with dichloromethane as the eluant. The fraction was collected and solvent was removed by rotovap, crude 1-bromo-3-(bromomethyl)-5-chlorobenzene (3) was obtained as a brown residue and used in the next step without further purification.

後処理

  1. customThe fraction was collected
  2. customsolvent was removed by rotovap

出典と根拠

ORDレコード
ord-f53ef18b613540c5be7d8fdee52053f2
出典データセット
uspto-grants-2007_09
特許番号
US07273882B2

反応ノート

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