Hydrochloric Acid → 1-(2-Methyl-5-pyridyl)-3-chloro-butan-1-ol hydrochloride

HRID 918066ノート

反応式

HRID 918066 の反応式
[Na].[CH3:2][C:3]1[CH:14]=[CH:13][C:6]([C:7]([CH2:9][C:10](=O)[CH3:11])=[O:8])=[CH:5][N:4]=1.[ClH:15].S(Cl)([Cl:18])=O>C1(C)C=CC=CC=1>[ClH:18].[CH3:2][C:3]1[CH:14]=[CH:13][C:6]([CH:7]([OH:8])[CH2:9][CH:10]([Cl:15])[CH3:11])=[CH:5][N:4]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 24386Thionyl ChlorideHCID 5360545SodiumHCID 202128141-(6-Methylpyridin-3-yl)butane-1,3-dione

生成物 1

HCID 215227241-(2-Methyl-5-pyridyl)-3-chloro-butan-1-ol hydrochloride

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A suspension of the sodium salt of 6-methyl-nicotinoyl-acetone in anhydrous toluene is saturated with hydrogen chloride and then reacted with thionyl chloride in a known manner. Reduction of the reaction product gives 1-(2-methyl-5-pyridyl)-3-chloro-butan-1-ol hydrochloride which is used without additional purification

出典と根拠

ORDレコード
ord-09cc5159f43545209b5bb40d30dae3f6
出典データセット
uspto-grants-1976_07
特許番号
US03969363

反応ノート

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