Thionyl Chloride → 2-Bromo-p-chlorophenylacetyl chloride

HRID 918577

反応式

HRID 918577 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][C:10]([OH:12])=O.S(Cl)([Cl:15])=O>>[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][C:10]([Cl:15])=[O:12]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 218285032-Bromo-4-chlorophenylacetic acid

生成物 1

HCID 197942342-Bromo-p-chlorophenylacetyl chloride収率 88.2%

実験手順

28.3g (0.113 mol) of 2-bromo-p-chlorophenylacetic acid was mixed with 26.9g (0.226 mol) of thionylchloride and the mixture was refluxed for 2.5 hours. After the excess thionylchloride had been distilled off, the reaction mixture was distilled under reduced pressure to give 26.7g of 2-bromo-p-chlorophenylacetyl chloride as yellow-orange oil. (b.p. 148° - 152°C/15 mmHg)

後処理

  1. temperaturethe mixture was refluxed for 2.5 hours
  2. distillationAfter the excess thionylchloride had been distilled off
  3. distillationthe reaction mixture was distilled under reduced pressure

出典と根拠

ORDレコード
ord-0a9b9b78ae254be2987c42d7e132ee20
出典データセット
uspto-grants-1976_07
特許番号
US03971828

関連ノート

読み込み中…