Maleimide → 3-(5-methyl-1H-indol-3-yl)pyrrolidine-2,5-dione
反応式
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[C:11]1(=[O:17])[NH:15][C:14](=[O:16])[CH:13]=[CH:12]1>C(O)(=O)C>[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:13]1[CH2:12][C:11](=[O:17])[NH:15][C:14]1=[O:16]参加物
4
実験手順
5-Methyl indole (10 g, 76 mmol) and maleimide (7.4 g, 76 mmol) in 77 mL of glacial acetic acid was heated at 90° C. for 24 h. The reaction mixture was cooled to RT, and the acetic acid was evaporated under reduced pressure. The residue was suspended in diethyl ether and filtered to obtain solid product (7 g).
後処理
- customthe acetic acid was evaporated under reduced pressure
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-e263406efc4e4511a115f4c8388cbe6a
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09271971B2
反応ノート
読み込み中…