Methanol → 2-Fluoro-4-(2-hydroxyethyl)phenol
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10](O)=[O:11])[CH:5]=[CH:6][C:7]=1[OH:8].B.CO>C1COCC1>[F:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][OH:11])[CH:5]=[CH:6][C:7]=1[OH:8]参加物
5
実験手順
To a solution of 2-(3-fluoro-4-hydroxyphenyl)acetic acid (9.8 g, 57.6 mmol) in THF (500 mL) was added dropwise 57.6 mL of borane (10M in Me2S) at room temperature. The reaction mixture was stirred at room temperature for 12 hours. The reaction mixture was added to CH3OH and was concentrated under reduced pressure. The residue was partitioned between EtOAc (800 mL) and water (100 mL). The organic layer was dried and concentrated to dryness to give the title product (8.5 g, 76%).
後処理
- concentrationwas concentrated under reduced pressure
- customThe residue was partitioned between EtOAc (800 mL) and water (100 mL)
- customThe organic layer was dried
- concentrationconcentrated to dryness
出典と根拠
- ORDレコード
- ord-96fe742a6f6944548b58cbf634560b95
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09273054B2
反応ノート
読み込み中…