Sodium Hydroxide → 3-(Trifluoromethoxy)cyclobutane-1-carboxylic acid
反応式
[F:1][C:2]([F:14])([F:13])[O:3][CH:4]1[CH2:7][CH:6]([C:8]([O:10]CC)=[O:9])[CH2:5]1.[OH-].[Na+]>C1COCC1.O>[F:1][C:2]([F:13])([F:14])[O:3][CH:4]1[CH2:7][CH:6]([C:8]([OH:10])=[O:9])[CH2:5]1参加物
5
反応条件
- 温度
- 60 °C
実験手順
To a stirred solution of Intermediate 212B (0.10 g, 0.47 mmol) in THF (5 mL) was added NaOH (0.038 g, 0.943 mmol) in water (1 mL) and the mixture was allowed to stir at 60° C. for 4 h. The reaction mixture was quenched with a 1.5 N aqueous solution of HCl and extracted with EtOAc (2×20 mL) The combined organic layers were dried over Na2SO4, filtered and the filtrate evaporated to afford Intermediate 212C as a light brown liquid (30 mg, 35% yield). 1H NMR (300 MHz, DMSO-d6) δ ppm 12.01-12.03 (bs, 1H), 3.34 (m, 2H), 1.04 (s, 6H).
後処理
- customThe reaction mixture was quenched with a 1.5 N aqueous solution of HCl
- extractionextracted with EtOAc (2×20 mL) The combined organic layers
- dry with materialwere dried over Na2SO4
- filtrationfiltered
- customthe filtrate evaporated
出典と根拠
- ORDレコード
- ord-ec937f7d400f4c7c8e3d1c2ba9daac33
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09273058B2
反応ノート
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