1-Methylimidazole → HCID 86662337、化合物

HRID 921996

反応式

HRID 921996 の反応式
[Cl:1][CH2:2][C:3]([O:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13](=[O:15])[CH3:14])=[CH:8][CH:7]=1)=[O:4].[CH3:16][N:17]1[CH:21]=[CH:20][N:19]=[CH:18]1>C(OCC)(=O)C>[Cl-:1].[C:13]([NH:12][C:9]1[CH:10]=[CH:11][C:6]([O:5][C:3](=[O:4])[CH2:2][N:19]2[CH:20]=[CH:21][N+:17]([CH3:16])=[CH:18]2)=[CH:7][CH:8]=1)(=[O:15])[CH3:14]

参加物

4

反応物 2

HCID 13901-MethylimidazoleHCID 132776644-Acetamidophenyl chloroacetate

生成物 1

HCID 86662337HCID 86662337、化合物収率 79%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

4-Acetamidophenyl 2-chloroacetate [2] (1.138 g, 5 mmol) and N-methylimidazol (0.492 g, 6 mmol) were suspended in 50 ml of anhydrous ethyl acetate and refluxed for 48 hrs. After cooling to room temperature the white precipitate was filtered, washed with ethylacetate and diethylether and dried under reduced pressure to give [3] in 79% yield. The product was pure according to 1H NMR and was directly subjected to the next step without further purification.

後処理

  1. temperaturerefluxed for 48 hrs
  2. filtrationwas filtered
  3. washwashed with ethylacetate and diethylether
  4. customdried under reduced pressure

出典と根拠

ORDレコード
ord-66f65af8eaf94b769d9526d19af39f97
出典データセット
uspto-grants-2016_03
特許番号
US09278134B2

関連ノート

読み込み中…