1-Ethenyl-4-(trifluoromethyl)benzene → 4-Ethylbenzotrifluoride

HRID 924671

反応式

HRID 924671 の反応式
[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][CH:4]=1)=[CH2:2]>C1COCC1.[Pd]>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]([F:10])([F:11])[F:12])=[CH:7][CH:8]=1)[CH3:2]

参加物

4

反応物 1

HCID 27827981-Ethenyl-4-(trifluoromethyl)benzene

生成物 1

HCID 53246974-Ethylbenzotrifluoride

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 1-ethenyl-4-(trifluoromethyl)benzene (1.72 mL, 11.6 mmol) in THF (60 mL) was stirred in the presence of Pd/C (10%, 400 mg), under a hydrogen atmosphere (45 psi) for 7 h. The solid was filtered through celite (washed with DCM) and the filtrate was carefully concentrated, keeping the temperature of the bath below 20° C. at 200 mmHg. The concentrated solution thus obtained was used in the next step without further manipulation.

後処理

  1. filtrationThe solid was filtered through celite (washed with DCM)
  2. concentrationthe filtrate was carefully concentrated
  3. customthe temperature of the bath below 20° C.
  4. customThe concentrated solution thus obtained

出典と根拠

ORDレコード
ord-be6e3d4980564493a300094b7485178b
出典データセット
uspto-grants-2016_03
特許番号
US09283224B2

関連ノート

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