Potassium Hydroxide → Amantadine
反応式
Cl.[C:2]12([NH2:12])[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([CH2:5]3)[CH2:3]1)[CH2:9]2.[OH-].[K+]>>[C:2]12([NH2:12])[CH2:9][CH:8]3[CH2:7][CH:6]([CH2:5][CH:4]([CH2:10]3)[CH2:3]1)[CH2:11]2参加物
3
実験手順
An aqueous solution of 1-adamantylamine hydrochloride (Alfa-Aesar, 99%) was treated with potassium hydroxide and extracted with toluene, dried over Na2SO4, filtered and stripped down by rotary evaporation to give 30.3 g 1-adamantylamine (200 mmol). The procedure for compound 1, above, was followed except the reaction was heated at 45° C. overnight yielding 26.23 g white solids (62.8 mmol, 63% yield). When performing the activated carbon treatment 2:1 water/absolute ethanol was used to dissolve the residue.
後処理
- extractionextracted with toluene
- dry with materialdried over Na2SO4
- filtrationfiltered
- customstripped down by rotary evaporation
出典と根拠
- ORDレコード
- ord-2a96ff9932fe44e98afecd7913bfb30a
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09289757B2
反応ノート
読み込み中…