Sodium sulfate decahydrate → (4-Phenylsulfanylmethyl-phenyl)-methanol

HRID 926994

反応式

HRID 926994 の反応式
[C:1]1([S:7][CH2:8][C:9]2[CH:18]=[CH:17][C:12]([C:13](OC)=[O:14])=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.O.O.O.O.O.O.O.O.O.S([O-])([O-])(=O)=O.[Na+].[Na+]>C1COCC1>[C:1]1([S:7][CH2:8][C:9]2[CH:10]=[CH:11][C:12]([CH2:13][OH:14])=[CH:17][CH:18]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 3

HCID 62649Sodium sulfate decahydrateHCID 366566Methyl 4-(phenylsulfanylmethyl)benzoateHCID 21226445Aluminium lithium hydride

生成物 1

HCID 59255239(4-Phenylsulfanylmethyl-phenyl)-methanol収率 95.4%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Methyl 4-(phenylsulfanylmethyl)benzoate (1.07 g) was dissolved in THF (14 mL), added with lithium aluminum hydride (200 mg) in small portions under ice cooling, and stirred for 40 minutes at the same temperature. Under ice cooling, sodium sulfate decahydrate was added in small portions and filtered through Celite. The solvent was evaporated under reduced pressure. The residues were suspended in hexane and collected by filtration to obtain the title compound (910 mg) as a white powder.

後処理

  1. filtrationfiltered through Celite
  2. customThe solvent was evaporated under reduced pressure
  3. filtrationcollected by filtration

出典と根拠

ORDレコード
ord-515455be59cd4491a9782fc76afb926c
出典データセット
uspto-grants-2016_03
特許番号
US09290440B2

関連ノート

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