Pyrrolidine → 2-(5-Bromo-2-pyrrolidin-1-ylphenyl)pteridin-4-one

HRID 928268

反応式

HRID 928268 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5](F)=[C:6]([C:8]2[NH:17][C:16](=[O:18])[C:15]3[C:10](=[N:11][CH:12]=[CH:13][N:14]=3)[N:9]=2)[CH:7]=1.[NH:20]1[CH2:24][CH2:23][CH2:22][CH2:21]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:20]2[CH2:24][CH2:23][CH2:22][CH2:21]2)=[C:6]([C:8]2[NH:17][C:16](=[O:18])[C:15]3[C:10](=[N:11][CH:12]=[CH:13][N:14]=3)[N:9]=2)[CH:7]=1

参加物

3

反応物 2

HCID 31268PyrrolidineHCID 1361099582-(5-Bromo-2-fluoro-phenyl)-3H-pteridin-4-one

生成物 1

HCID 1361099572-(5-Bromo-2-pyrrolidin-1-ylphenyl)pteridin-4-one

実験手順

A solution of 2-(5-bromo-2-fluorophenyl)pteridin-4-one 104 in pyrrolidine was heated in a microwave cavity (Power=270 W, Temp=110° C.) for 12 min. The pyrrolidine was evaporated, then residue partitioned between NaHCO3 0.5 N and CH2Cl2, dried (Na2SO4) and evaporated. Trituration in Et2O afforded the title product 110 as a yellow powder (LCMS analysis).

後処理

  1. customThe pyrrolidine was evaporated
  2. customresidue partitioned between NaHCO3 0.5 N and CH2Cl2
  3. dry with materialdried (Na2SO4)
  4. customevaporated

出典と根拠

ORDレコード
ord-bcd291c8f63c4093805a96ab93d1a512
出典データセット
uspto-grants-2016_03
特許番号
US09290502B2

関連ノート

読み込み中…