Hydroxyamine hydrochloride → 3,5-Difluoro-4-((hydroxyimino)methyl)benzonitrile
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:12])[C:9]=1[CH:10]=O)[C:5]#[N:6].Cl.[NH2:14][OH:15].C([O-])(=O)C.[K+]>CO>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:12])[C:9]=1[CH:10]=[N:14][OH:15])[C:5]#[N:6]参加物
5
反応条件
- 温度
- 60 °C
実験手順
A mixture of 3,5-difluoro-4-formylbenzonitrile (500 mg, 3.0 mmol), hydroxylamine hydrochloride (207 mg, 3.0 mmol) and potassium acetate (586 mg, 6.0 mmol) in methanol (10 mL) was heated to 60° C. for 1 h then concentrated in vacuo and purified by column chromatography (eluent: DCM) to afford 3,5-difluoro-4-((hydroxyimino)methyl)benzonitrile (130 mg, 0.7 mmol) as a white solid.
後処理
- concentrationthen concentrated in vacuo
- custompurified by column chromatography (eluent: DCM)
出典と根拠
- ORDレコード
- ord-d6c74245b79441fd9cbd77aeeca64ec0
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09296725B2
反応ノート
読み込み中…