Tetrahydrofuran → 1469286-32-5

HRID 931073ノート

反応式

HRID 931073 の反応式
[N:1]1([C:6]2([C:10]([O:12]CC)=[O:11])[CH2:9][CH2:8][CH2:7]2)[CH:5]=[CH:4][CH:3]=[N:2]1.O1CCCC1.[OH-].[Na+]>O>[N:1]1([C:6]2([C:10]([OH:12])=[O:11])[CH2:7][CH2:8][CH2:9]2)[CH:5]=[CH:4][CH:3]=[N:2]1

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 89853540HCID 89853540、化合物

生成物 1

HCID 898542991469286-32-5収率 18.5%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To ethyl 1-(1H-pyrazol-1-yl)cyclobutanecarboxylate (688 mg, 3.54 mmol) were added tetrahydrofuran (8 mL) and water (0.9 mL). Aqueous sodium hydroxide (1N, 4 mL, 4 mmol) was added to the mixture. The reaction mixture was stirred at room temperature for 18 h. The solvent was removed under reduced pressure and to the residue was added aqueous hydrochloric acid (1N, 1 mL). The mixture was extracted with dichloromethane (3×). The combined organics were dried over magnesium sulfate, filtered and concentrated under reduced pressure to afford the title compound (108.9 mg). The material was used without further purification.

後処理

  1. customThe solvent was removed under reduced pressure and to the residue
  2. additionwas added aqueous hydrochloric acid (1N, 1 mL)
  3. extractionThe mixture was extracted with dichloromethane (3×)
  4. dry with materialThe combined organics were dried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-16f5c9efd5a349688e59bd5abc6c5a17
出典データセット
uspto-grants-2016_03
特許番号
US09296745B2

反応ノート

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