2-Fluoroaniline → 544662-80-8
反応式
[CH2:1]([S:3](Cl)(=[O:5])=[O:4])[CH3:2].[F:7][C:8]1[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=1[NH2:10]>C(Cl)Cl.N1C=CC=CC=1.CCOC(C)=O>[F:7][C:8]1[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=1[NH:10][S:3]([CH2:1][CH3:2])(=[O:5])=[O:4]参加物
6
反応条件
- 温度
- 50 °C
実験手順
To a solution of ethanesulfonyl chloride (0.368 ml, 3.89 mmol) in DCM (1 ml) and pyridine (1 ml) was added 2-fluoroaniline (0.360 ml, 3.89 mmol) at rt and the reaction was stirred at 50° C. for 5 hours. The reaction was then stirred at rt overnight. The reaction was diluted with EtOAc and washed with H2O and sat. NaCl solution. The organic layer was dried over Na2SO4 and concentrated. Purification of the residue by flash chromatography on silica gel (eluent: 0% to 35% EtOAc/hexane) provided the title compound as a white solid.
後処理
- stirringThe reaction was then stirred at rt overnight
- washwashed with H2O and sat. NaCl solution
- dry with materialThe organic layer was dried over Na2SO4
- concentrationconcentrated
- customPurification of the residue by flash chromatography on silica gel (eluent: 0% to 35% EtOAc/hexane)
出典と根拠
- ORDレコード
- ord-14ecb425d14c4641893dbcdac1ff90e2
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09296736B2
反応ノート
読み込み中…