Ethyl bromoacetate → Ethyl 2-(2-(trifluoromethyl)phenoxy)acetate
反応式
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9].C(=O)([O-])[O-].[Cs+].[Cs+].Br[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21]>C(#N)C.O.C(OCC)(=O)C>[CH2:23]([O:22][C:20](=[O:21])[CH2:19][O:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:2]([F:10])([F:11])[F:1])[CH3:24]参加物
7
実験手順
A mixture of 2-trifluoromethylphenol (1.62 g) in anhydrous acetonitrile was treated with cesium carbonate (3.25 g) and ethyl bromoacetate (1.75 g) and the reaction mixture stirred at room temperature for 2 hours. The reaction mixture was diluted with water and ethyl acetate and the organic layer washed with water and dried with brine and over sodium sulfate. Evaporation of ethyl acetate gave the title compound as a colourless oil.
後処理
- washthe organic layer washed with water
- dry with materialdried with brine and over sodium sulfate
- customEvaporation of ethyl acetate
出典と根拠
- ORDレコード
- ord-6d696bea668f4b758ccefed342a68beb
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07091237B2
反応ノート
読み込み中…