Ethyl bromoacetate → Ethyl 2-(2-(trifluoromethyl)phenoxy)acetate

HRID 9623

反応式

HRID 9623 の反応式
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9].C(=O)([O-])[O-].[Cs+].[Cs+].Br[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21]>C(#N)C.O.C(OCC)(=O)C>[CH2:23]([O:22][C:20](=[O:21])[CH2:19][O:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:2]([F:10])([F:11])[F:1])[CH3:24]

参加物

7

反応物 3

HCID 7748Ethyl bromoacetateHCID 10796Cesium carbonateHCID 679582-Trifluoromethylphenol

生成物 1

HCID 11354946Ethyl 2-(2-(trifluoromethyl)phenoxy)acetate

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 6342Acetonitrile溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 2-trifluoromethylphenol (1.62 g) in anhydrous acetonitrile was treated with cesium carbonate (3.25 g) and ethyl bromoacetate (1.75 g) and the reaction mixture stirred at room temperature for 2 hours. The reaction mixture was diluted with water and ethyl acetate and the organic layer washed with water and dried with brine and over sodium sulfate. Evaporation of ethyl acetate gave the title compound as a colourless oil.

後処理

  1. washthe organic layer washed with water
  2. dry with materialdried with brine and over sodium sulfate
  3. customEvaporation of ethyl acetate

出典と根拠

ORDレコード
ord-6d696bea668f4b758ccefed342a68beb
出典データセット
uspto-grants-2006_08
特許番号
US07091237B2

関連ノート

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