tert-Butanol → 86023-87-2

HRID 962392ノート

反応式

HRID 962392 の反応式
Br[C@H:2]1[C:28](=[O:29])[C@@:27]2([CH3:30])[C@@H:13]([CH2:14][C@@H:15]3[O:20][C@@:19]4([O:26][CH2:25][C@H:23]([CH3:24])[CH2:22][CH2:21]4)[C@@H:17]([CH3:18])[C@@H:16]32)[C@H:12]2[C@H:3]1[C@:4]1([CH3:32])[C@@H:9]([CH2:10][CH2:11]2)[CH2:8][C@@H:7]([OH:31])[CH2:6][CH2:5]1.C([OH:37])(C)(C)C.[OH-].[Na+]>O>[CH3:18][C@@H:17]1[C@:19]2([O:26][CH2:25][C@H:23]([CH3:24])[CH2:22][CH2:21]2)[O:20][C@H:15]2[CH2:14][C@@H:13]3[C@@:27]([CH3:30])([C@@H:16]12)[C@H:28]([OH:29])[C:2](=[O:37])[C@H:3]1[C@H:12]3[CH2:11][CH2:10][C@@H:9]2[C@:4]1([CH3:32])[CH2:5][CH2:6][C@H:7]([OH:31])[CH2:8]2

参加物

5

反応物 3

HCID 6386tert-ButanolHCID 14798Sodium HydroxideHCID 10673254HCID 10673254、化合物

生成物 1

HCID 15891086023-87-2

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
83 °C

実験手順

A glass lined reactor was charged with 12.4 Kg of (3β,5α,11β,25R)-11-bromospirostan-3-ol-12-one (24.34 mole), 33 gallons of t-butanol, 33 gallons of water and 7.5 Kg (189 mole, 7.75 eq) of sodium hydroxide pellets. The reaction was heated to reflux over 1.5 hours, maintained at reflux for 4.5 hours (pot temperature was 83° C.), then cooled to room temperature. TLC at this point indicated complete reaction.

後処理

  1. temperatureThe reaction was heated
  2. temperatureto reflux over 1.5 hours
  3. temperaturemaintained
  4. temperaturecooled to room temperature
  5. customreaction

出典と根拠

ORDレコード
ord-f35b277aa025424781d64a28bcb251ba
出典データセット
uspto-grants-1998_06
特許番号
US05760009

反応ノート

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