Water → 1-(4-Acetylamino-5-chloro-2-methoxyphenyl)-5-(piperidin-1-yl)pentan-1-one

HRID 963343

反応式

HRID 963343 の反応式
[C:1]([NH:4][C:5]1[C:10]([Cl:11])=[CH:9][C:8]([C:12](=[O:18])[CH2:13][CH2:14][CH2:15][CH2:16]Cl)=[C:7]([O:19][CH3:20])[CH:6]=1)(=[O:3])[CH3:2].[I-].[Na+].[NH:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1.O>CN(C=O)C>[C:1]([NH:4][C:5]1[C:10]([Cl:11])=[CH:9][C:8]([C:12](=[O:18])[CH2:13][CH2:14][CH2:15][CH2:16][N:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)=[C:7]([O:19][CH3:20])[CH:6]=1)(=[O:3])[CH3:2]

参加物

6

反応物 4

HCID 962WaterHCID 5238Sodium IodideHCID 8082PiperidineHCID 190818611-(4-Acetylamino-5-chloro-2-methoxyphenyl)-5-chloropentan-1-one

生成物 1

HCID 190819331-(4-Acetylamino-5-chloro-2-methoxyphenyl)-5-(piperidin-1-yl)pentan-1-one収率 96.5%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
80 °C

実験手順

1-(4-Acetylamino-5-chloro-2-methoxyphenyl)-5-chloropentan-1-one (0.72 g, 2.26 mmol), sodium iodide (0.15 g, 0.1 mmol), and piperidine (1.72 g, 20 mmol) were combined in DMF (8.0 mL) and the mixture was heated to 80° C. for 4.5 hours. Water was then added to form a precipitate. Filtration gave 1-(4-acetylamino-5-chloro-2-methoxyphenyl)-5-(piperidin-1-yl)pentan-1-one (0.8 g, 2.18 mmol), m.p. 74°-75° C.

後処理

  1. customto form a precipitate
  2. filtrationFiltration

出典と根拠

ORDレコード
ord-961cf621db1c4e61b496032ab17b2b88
出典データセット
uspto-grants-1998_06
特許番号
US05763458

関連ノート

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