反応式
[H-].[Na+].Cl[C@@H:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][C@H:5]1[NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15].C1OCCOCCOCCOCCOC1.O>O1CCCC1>[C:17]([O:16][C:14]([N:13]1[CH:5]2[CH2:6][C:7]3[C:12]([CH:4]12)=[CH:11][CH:10]=[CH:9][CH:8]=3)=[O:15])([CH3:20])([CH3:19])[CH3:18]参加物
6
反応条件
- 温度
- 50 °C
実験手順
To a suspension of NaH (80% disp. in oil, 2.016 g, 67.2 mmol) in dry tetrahydrofuran (300 ml) was added (±)trans-1-chloro-2-tert-butoxycarbonylaminoindane (15 g, 56 mmol) and 15-crown-5 (50 μl). The mixture was then warmed at 50° C. under nitrogen for 18 h after which it was poured into water (700 ml) and extracted with diethyl ether (3×150 ml). The combined organic extracts were dried (Na2SO4) and solvents were removed in vacuo to afford the title compound as a brown solid (12.67 g).
後処理
- extractionextracted with diethyl ether (3×150 ml)
- dry with materialThe combined organic extracts were dried (Na2SO4) and solvents
- customwere removed in vacuo
出典と根拠
- ORDレコード
- ord-ff8e09e9077649299429b0659c3cc44a
- 出典データセット
- uspto-grants-1998_06
- 特許番号
- US05773463
関連ノート
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