Perchloric Acid → HCID 22116111、化合物
反応式
[Cl:1][CH2:2][CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=O)[C:5]1=[O:14].Cl(O)(=O)(=O)=O>C(O)(=O)C.[Pd]>[Cl:1][CH2:2][CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][C:5]1=[O:14]参加物
5
実験手順
1-(2-Chloroethyl)-lH-indol-2,3-dione (5.24 g) [C.A. Reg no. 77218-99-6] was suspended in acetic acid (50 ml) and hydrogenated at 60 p.s.i., at room temperature, in the presence of 70% perchloric acid (0.2 ml) and 5% palladium on charcoal (1 g) for 24 hours. The clear solution was filtered and concentrated under reduced pressure. The residue was purified by chromatography on silica gel, eluent chloroform, to give 1-(2-chloroethyl)-1,3-dihydro-2H-indol-2-one as a white solid.
後処理
- filtrationThe clear solution was filtered
- concentrationconcentrated under reduced pressure
- customThe residue was purified by chromatography on silica gel, eluent chloroform
出典と根拠
- ORDレコード
- ord-e50f9d551456438196f57063bd6952ee
- 出典データセット
- uspto-grants-1998_06
- 特許番号
- US05773448
反応ノート
読み込み中…