Oxalyl chloride → 1-(Cyclohexylmethyl)-7-methoxyindole-3-carbonyl chloride

HRID 968637ノート

反応式

HRID 968637 の反応式
[CH:1]1([CH2:7][N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][C:15]=3[O:17][CH3:18])[C:10]([C:19]([OH:21])=O)=[CH:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(Cl)(=O)C([Cl:25])=O>C1COCC1>[CH:1]1([CH2:7][N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][C:15]=3[O:17][CH3:18])[C:10]([C:19]([Cl:25])=[O:21])=[CH:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 686950531-(Cyclohexylmethyl)-7-methoxyindole-3-carboxylic acid

生成物 1

HCID 859058491-(Cyclohexylmethyl)-7-methoxyindole-3-carbonyl chloride収率 100.3%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 1-(cyclohexylmethyl)-7-methoxyindole-3-carboxylic acid (2.5 g, 8.8 mmol) in THF (30 ml) was added oxalyl chloride (4.5 g, 35.3 mmol), dropwise with stirring. The mixture was stirred at room temperature for 18 h. The volatile components were evaporated under reduced pressure to afford 1-(cyclohexylmethyl)-7-methoxyindole-3-carbonyl chloride (2.7 g) as a crystalline solid.

後処理

  1. stirringThe mixture was stirred at room temperature for 18 h
  2. customThe volatile components were evaporated under reduced pressure

出典と根拠

ORDレコード
ord-af31ea58d986444ca2e570dd23ae8857
出典データセット
uspto-grants-2007_12
特許番号
US07304064B2

反応ノート

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