Water → (R)-Octahydro-pyrido[1,2-a]pyrazine

温度

0 °C

(R)-Octahydro-1,4-dioxo-2H-pyrido[1,2-a]pyrazine (0.5 g, 2.98 mmol) was added portionwise to a stirred solution of lithium aluminium hydride (1M in tetrahydrofuran; 11.9 ml, 11.9 mmol). The resulting mixture was heated under reflux for 0.5 h. The solution was then cooled to 0° C. and treated dropwise with water (1.35 ml), 1 M sodium hydroxide solution (0.45 ml), then water (1.35 ml). Tetrahydrofuran (10 ml) was added and the solution stirred for 0.5 h, before filtration. The filter cake was washed with tetrahydrofuran (2×5 ml) and the combined filtrate and washings concentrated to yield (R)-octahydro-2H-pyrido[1,2-a]pyrazine as a yellow oil (0.29 g, 2.07 mmol).

1. temperatureThe resulting mixture was heated
2. temperatureunder reflux for 0.5 h
3. washThe filter cake was washed with tetrahydrofuran (2×5 ml)
4. concentrationthe combined filtrate and washings concentrated

ORDレコード

ord-d8177b0d07644d80a3a48c4387a17559

出典データセット

uspto-grants-2007_12

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07304064B2