Hydrochloric Acid → 6-(2-methoxyethoxymethoxy)-2-naphthoic acid

HRID 969476

反応式

HRID 969476 の反応式
[OH-].[Na+].[CH3:3][O:4][CH2:5][CH2:6][O:7][CH2:8][O:9][C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[CH:16]=[C:15]([C:20]([O:22]C)=[O:21])[CH:14]=[CH:13]2.Cl>O1CCCC1.CO.O>[CH3:3][O:4][CH2:5][CH2:6][O:7][CH2:8][O:9][C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[CH:16]=[C:15]([C:20]([OH:22])=[O:21])[CH:14]=[CH:13]2

参加物

7

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12085484Methyl 6-(2-methoxyethoxymethoxy)naphthalene-2-carboxylate

生成物 1

HCID 120854856-(2-methoxyethoxymethoxy)-2-naphthoic acid収率 93%

試薬・触媒・溶媒 3

HCID 962Water触媒HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

12.9 g (325 mmol) of sodium hydroxide pellets are added to a solution of 16.9 g (58 mmol) of methyl 6-(2-methoxyethoxymethoxy)naphthalene-2-carboxylate in 200 ml of tetrahydrofuran, 20 ml of methanol and a few drops of water, and the reaction medium is stirred at room temperature for 4 hours. Next, aqueous 1N hydrochloric acid solution is added until pH=2 is obtained, and the reaction medium is extracted with ethyl acetate, dried over sodium sulfate, filtered and concentrated under vacuum. The residue obtained is washed with heptane and filtered. 14.9 g of 6-(2-methoxyethoxymethoxy)-2-naphthoic acid are obtained in the form of a white solid, in a yield of 92%.

後処理

  1. customis obtained
  2. extractionthe reaction medium is extracted with ethyl acetate
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under vacuum
  6. customThe residue obtained
  7. washis washed with heptane
  8. filtrationfiltered

出典と根拠

ORDレコード
ord-479e6b9a53a245dea2ec7495b60678ca
出典データセット
uspto-grants-2007_12
特許番号
US07307078B2

関連ノート

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