Sodium Carbonate → 4-Hydroxy-4-(5-methyl-thiazol-2-yl)-cyclohexanone
反応式
[CH3:1][C:2]1[S:6][C:5]([C:7]2([OH:17])[CH2:16][CH2:15][C:10]3(OCC[O:11]3)[CH2:9][CH2:8]2)=[N:4][CH:3]=1.C([O-])([O-])=O.[Na+].[Na+]>C1COCC1>[OH:17][C:7]1([C:5]2[S:6][C:2]([CH3:1])=[CH:3][N:4]=2)[CH2:16][CH2:15][C:10](=[O:11])[CH2:9][CH2:8]1参加物
4
実験手順
A solution of 8-(5-methyl-1,3-thiazol-2-yl)-1,4-dioxaspiro[4.5]decan-8-ol (1.0 g, 4.14 mmol) in 20 mL of THF/3 N HCl (1:1) was stirred for 1 h at 50° C. After cooling to room temperature, the mixture was treated with Na2CO3 to pH 8 and extracted with EtOAc three times. The combined organic layers were washed with saturated NaCl solution, dried (MgSO4), and concentrated to give 0.82 g (99%) of the desired product. MS (M+H)+=212.2.
後処理
- extractionextracted with EtOAc three times
- washThe combined organic layers were washed with saturated NaCl solution
- dry with materialdried (MgSO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-30025fdf142c419c970ac8a470e80207
- 出典データセット
- uspto-grants-2007_12
- 特許番号
- US07307086B2
反応ノート
読み込み中…