Hydrazine hydrate (1:1) → HCID 25219120、化合物

HRID 970269ノート

反応式

HRID 970269 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][CH:20]=1)[C:5]([NH:7][C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][CH:17]=1)[C:11](OC)=[O:12])=[O:6].O.[NH2:22][NH2:23]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][CH:20]=1)[C:5]([NH:7][C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][CH:17]=1)[C:11]([NH:22][NH2:23])=[O:12])=[O:6]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 723590Methyl 3-(3-chlorobenzamido)benzoate

生成物 1

HCID 25219120HCID 25219120、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
65 °C

実験手順

To a solution of 1.0 gm (3.45 mmol) of methyl 3-(3-chlorobenzamido)benzoate in 24 mL of tetrahydrofuran was added 1.18 mL (34.5 mmol) of hydrazine hydrate. The reaction was heated overnight at 65° C. After cooling, the reaction mixture was concentrated under rotevaporation, and ether and water were added. The solid product was separated by filtration and dried in vacuo to give 3-(3-chlorobenzamido)benzhydrazide. MS m/z: 290.0 (M+H).

後処理

  1. temperatureAfter cooling
  2. concentrationthe reaction mixture was concentrated under rotevaporation, and ether and water
  3. additionwere added
  4. customThe solid product was separated by filtration
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-6529c36448a44ac8944a27281a11de38
出典データセット
uspto-grants-2007_12
特許番号
US07312181B2

反応ノート

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