1-Bromohexadecane → HCID 20396833、化合物

HRID 971957ノート

反応式

HRID 971957 の反応式
[CH2:1]([C:3]1[N:7]2[CH2:8][CH2:9][CH2:10][N:11]=[C:6]2[S:5][C:4]=1[CH3:12])[CH3:2].C(=O)([O-])[O-].[Na+].[Na+].[CH2:19]([Br:35])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]>C(#N)C>[Br-:35].[CH2:34]([N:11]1[CH2:10][CH2:9][CH2:8][N+:7]2[C:3]([CH2:1][CH3:2])=[C:4]([CH3:12])[S:5][C:6]1=2)[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH3:19]

参加物

5

反応物 3

HCID 82131-BromohexadecaneHCID 10340Sodium CarbonateHCID 203968403-Ethyl-2-methyl-6,7-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine

生成物 1

HCID 20396833HCID 20396833、化合物収率 18.9%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
0 °C

実験手順

3-Ethyl-2-methyl-6,7-dihydro-[5H]-thiazolo[3,2-a]pyrimidine (1.8 g., 0.01 mole) (prepared by basification of the hydrobromide salt with sodium carbonate) and cetyl bromide (3.3 g., 0.011 mole) were refluxed in acetonitrile solution for 16 hours. The solvent was evaporated and the residual oil solidified by stirring under dry ether at 0° C. Recrystallization from a mixture of acetonitrile and ether gave 8-cetyl-3-ethyl-2-methyl-6,7-dihydro[5H]thiazolo[3,2-a]pyrimidinium bromide, (0.92 g., 20%), m.p. 63°-66° (Found: C, 61.4; H, 9.6; N, 5.6. C25H47N2SBr requires C, 61.6; H, 9.7; N, 5.7%).

後処理

  1. customThe solvent was evaporated
  2. customRecrystallization
  3. additionfrom a mixture of acetonitrile and ether

出典と根拠

ORDレコード
ord-8673abee883d48ceaa6f41514913c0ac
出典データセット
uspto-grants-1979_07
特許番号
US04162253

反応ノート

読み込み中…