p-Toluenesulfonic acid → 2,4-Dimethyl-6-tert-butylphenol

HRID 972084

反応式

HRID 972084 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[OH:9].[C:10]1([CH3:20])[CH:15]=CC(S(O)(=O)=O)=C[CH:11]=1.CC(=C)C>C1(C)C=CC=CC=1>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([C:10]([CH3:20])([CH3:15])[CH3:11])[C:3]=1[OH:9]

参加物

5

反応物 3

HCID 6101p-Toluenesulfonic acidHCID 77712,4-DimethylphenolHCID 8255Isobutylene

生成物 1

HCID 158842,4-Dimethyl-6-tert-butylphenol収率 2,443.9%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a 1 liter flask equipped with a condenser, over-head stirrer, and gas inlet tube was added 2,4-dimethylphenol (200 g, 1.64 m.), toluene (400 ml), and p-toluenesulfonic acid (10 g). After heating this solution to reflux, isobutylene was added continuously for 14 hrs. Upon cooling, the solution was washed twice with water (400 ml), dried (MgSO4), and the solvent evaporated to afford a dark brown liquid. GC confirmed that this liquid was about 72% product. Distillation afforded 253 g (86.6%) of clear product which was shown to be 97% pure by GC.

後処理

  1. customTo a 1 liter flask equipped with a condenser, over-head stirrer, and gas inlet tube
  2. temperatureAfter heating this solution
  3. temperatureto reflux
  4. temperatureUpon cooling
  5. washthe solution was washed twice with water (400 ml)
  6. dry with materialdried (MgSO4)
  7. customthe solvent evaporated
  8. customto afford a dark brown liquid
  9. distillationDistillation

出典と根拠

ORDレコード
ord-9176f10901fa4680be16313bc4c3bfdd
出典データセット
uspto-grants-1979_07
特許番号
US04163008

関連ノート

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