Guanidine → Diaveridine

HRID 972363ノート

反応式

HRID 972363 の反応式
[CH:1](=O)[C:2]1[CH:11]=[CH:10][C:7]([O:8][CH3:9])=[C:4]([O:5][CH3:6])[CH:3]=1.C[N:14](C)[CH2:15][CH2:16][C:17]#N.[Na].[NH2:21][C:22]([NH2:24])=[NH:23]>C(O)C>[NH2:23][C:22]1[N:24]=[C:15]([NH2:14])[C:16]([CH2:1][C:2]2[CH:11]=[CH:10][C:7]([O:8][CH3:9])=[C:4]([O:5][CH3:6])[CH:3]=2)=[CH:17][N:21]=1

参加物

6

反応物 4

HCID 3520GuanidineHCID 8419VeratraldehydeHCID 15615DimethylaminopropionitrileHCID 5360545Sodium

生成物 1

HCID 21453Diaveridine収率 32%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The aforesaid British patent specification No. 957,797 also describes (Example 14) the reaction of veratraldehyde with β-dimethylaminopropionitrile in the presence of sodium in ethanol to give a mixture of β-dimethylaminoveratralnitrile (III) and β-ethoxyveratralnitrile (IV) in a 32% yield. ##STR4## It is stated in the Example that this mixture was subsequently cyclised with guanidine to give 2,4-diamino-5-(3',4'-dimethoxybenzyl)-pyrimidine. It is to be noted that both the compounds (III) and (IV) above are `benzal` derivatives.

後処理

  1. customto give

出典と根拠

ORDレコード
ord-bdd13e7fc0aa43f0827485d86f2cf737
出典データセット
uspto-grants-1977_10
特許番号
US04052553

反応ノート

読み込み中…