Trifluoroacetic acid → Ethyl 6-ethyl-3,4-dihydro-5-hydroxy-4-oxothieno[2,3-d]PYRIMIDINE-2-CARBOXYLATE

HRID 973044

反応式

HRID 973044 の反応式
N[C:2]1[C:10]2[C:9](=[O:11])[NH:8][C:7]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[N:6][C:5]=2[S:4][C:3]=1[CH2:17][CH3:18].[B-](F)(F)(F)F.FC(F)(F)C([O-])=[O:27].[K+].FC(F)(F)C(O)=O>>[CH2:17]([C:3]1[S:4][C:5]2[N:6]=[C:7]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[NH:8][C:9](=[O:11])[C:10]=2[C:2]=1[OH:27])[CH3:18]

参加物

5

反応物 4

HCID 6422Trifluoroacetic acidHCID 26255TetrafluoroborateHCID 12516925Ethyl 5-amino-6-ethyl-3,4-dihydro-4-oxothieno[2,3-d]PYRIMIDINE-2-CARBOXYLATEHCID 23662811Potassium trifluoroacetate

生成物 1

HCID 23330393Ethyl 6-ethyl-3,4-dihydro-5-hydroxy-4-oxothieno[2,3-d]PYRIMIDINE-2-CARBOXYLATE

反応条件

温度
25 °C

実験手順

The diazonium fluoroborate salt is prepared as in Procedure 63 from the amino compound produced in Procedure 51 yielding 0.03 mole of the required idazonium fluoborate. The latter is added in one portion to a solution of 0.03 mole of potassium trifluoroacetate in 13 ml. of trifluoroacetic acid at 0° C. The mixture is stirred at 25° C. for 1 hour and then refluxed overnight. The trifluoroacetic acid is evaporated in vacuo to give a residue which is triturated with water and filtered to give the desired product.

後処理

  1. customat 0° C
  2. temperaturerefluxed overnight
  3. customThe trifluoroacetic acid is evaporated in vacuo
  4. customto give a residue which
  5. customis triturated with water
  6. filtrationfiltered

出典と根拠

ORDレコード
ord-2d90e88b0aae47a48537ed6a9b4507da
出典データセット
uspto-grants-1977_10
特許番号
US04054656

関連ノート

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