Sodium Chloride → HCID 15667144、化合物

HRID 973770

反応式

HRID 973770 の反応式
[Na].[CH3:2][C@@H:3]1[C@@H:21]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[N:6]2[C:7](Cl)=[N:8][C:9]3[N:13]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[N:12]=[CH:11][C:10]=3[C:5]2=[N:4]1.[O-:28][CH2:29][CH2:30][CH3:31].[Na+].[Cl-]>C(O)CC>[CH3:2][C@@H:3]1[C@@H:21]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[N:6]2[C:7]([O:28][CH2:29][CH2:30][CH3:31])=[N:8][C:9]3[N:13]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[N:12]=[CH:11][C:10]=3[C:5]2=[N:4]1

参加物

6

反応物 4

HCID 5234Sodium ChlorideHCID 5360545SodiumHCID 125435151-Propanol, ion(1-)HCID 15667140HCID 15667140、化合物

生成物 1

HCID 15667144HCID 15667144、化合物

試薬・触媒・溶媒 1

HCID 10311-Propanol溶媒2 回

実験手順

51 mg sodium was dissolved in 5 ml n-propanol. 670 mg of the above product (2R-trans)-2,7-dihydro-2-methyl-3,7-diphenyl-5-chloro-3H-imidazo[1,2-c]pyrazolo[4,3-e]pyrimidine dissolved in 15 ml n-propanol was added to the propoxide solution with stirring. After 1 hour the reaction was poured into 200 ml saturated NaCl and the extracts were dried over MgSO4, filtered and concentrated to yield an oil which was purified by radial chromatography (30-50-70-90% ethanol/ hexane, 2 mm plate) to yield 600 mg of (2R-trans)-2,7-dihydro-2-methyl-3,7-diphenyl-5-propoxy-3H-imidazo[1,2-c]pyrazolo[4,3-e]pyrimidine.

後処理

  1. dry with materialthe extracts were dried over MgSO4
  2. filtrationfiltered
  3. concentrationconcentrated
  4. customto yield an oil which
  5. customwas purified by radial chromatography (30-50-70-90% ethanol/ hexane, 2 mm plate)

出典と根拠

ORDレコード
ord-977b111411004781a6cca546565ac9e0
出典データセット
uspto-grants-1991_11
特許番号
US05064947

関連ノート

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