2-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepine → 2-Amino-6-(4-phenyl-3-buten-1-yl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine

HRID 974316

反応式

[C:1]1([CH:7]=[CH:8][CH2:9][CH2:10]Br)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:12][C:13]1[S:14][C:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20][C:21]=2[N:22]=1.C(Cl)(Cl)Cl.C1(C)C=CC=CC=1>C(Cl)(Cl)Cl>[NH2:12][C:13]1[S:14][C:15]2[CH2:16][CH2:17][N:18]([CH2:10][CH2:9][CH:8]=[CH:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[CH2:19][CH2:20][C:21]=2[N:22]=1

参加物

実験手順

Prepared analogously to Example 8 from 4-phenyl-3-buten-1-yl-bromide [boiling point 93° C./1,5 torr; prepared from 1-cyclopropyl-1-phenyl-carbinol with phosphorous tribromide] with 4 equivalents of 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine in pure chloroform during 8 hours at 60° C. Yield: 39% of theory, Melting point: 157°-158° C. (chloroform/toluene)

出典と根拠

ORDレコード: ord-8898850d1f58481ca25678d839724852
出典データセット: uspto-grants-1991_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05068325

反応式

参加物

反応物 3

生成物 1

試薬・触媒・溶媒 1

実験手順

出典と根拠

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