Potassium Sodium Tartrate → 1,4-Butanediol, 2,2-diphenyl-

HRID 975111

反応式

HRID 975111 の反応式
[C:1]1([C:7]2([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH2:12][CH2:11][O:10][C:8]2=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].[C@H](O)(C([O-])=O)[C@@H](O)C([O-])=O.[Na+].[K+]>C1COCC1>[C:1]1([C:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)([CH2:12][CH2:11][OH:10])[CH2:8][OH:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 3

HCID 9357Potassium Sodium TartrateHCID 70393Dihydro-3,3-diphenyl-2(3H)-furanoneHCID 21226445Aluminium lithium hydride

生成物 1

HCID 112419701,4-Butanediol, 2,2-diphenyl-収率 98.3%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

In anhydrous THF (80 ml) was dissolved α,α-diphenyl-γ-butyrolactone (7 g) followed by addition of lithium aluminum hydride (1 g) with ice-cooling, and the mixture was stirred under the same conditions for 3 hours. Then, under ice-cooling, a saturated aqueous solution of Rochelle salt was added dropwise to precipitate the aluminum and other inorganic matter. The supernatant was taken by decantation, dried and concentrated under reduced pressure. The residue was recrystallized from isopropyl ether to provide 2,2-diphenyl-1,4-butanediol (7 g).

後処理

  1. temperaturecooling
  2. temperatureThen, under ice-cooling
  3. customto precipitate the aluminum and other inorganic matter
  4. customdried
  5. concentrationconcentrated under reduced pressure
  6. customThe residue was recrystallized from isopropyl ether

出典と根拠

ORDレコード
ord-45049620f24a441a9c4d9dd562ca185b
出典データセット
uspto-grants-1997_03
特許番号
US05607939

関連ノート

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