Pyridine → 1-Phenyl-1-cyclopentanecarboxaldehyde oxime

HRID 975265ノート

反応式

HRID 975265 の反応式
[C:1]1([C:7]2([CH:12]=O)[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl-].[OH:15][NH3+:16].N1C=CC=CC=1>C(O)C>[C:1]1([C:7]2([CH:12]=[N:16][OH:15])[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 21645Hydroxylamine HClHCID 110951241-Phenylcyclopentane-1-carbaldehyde

生成物 1

HCID 736783341-Phenyl-1-cyclopentanecarboxaldehyde oxime収率 66%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of the above aldehyde (3.4 g, 20 mmol) and hydroxylammonium chloride (2.9 g, 42 mmol) in a mixture of absolute ethanol (30 ml) and pyridine (3.3 g, 42 mmol) was heated at reflux for 2 h. The solvent was evaporated in vacuo, the residue was treated with absolute ethanol (50 ml) and the suspension filtered. The solvent was evaporated from the filtrate in vacuo and the residue crystallised from a 4/1 mixture of n-heptane and ethyl acetate to give 2.5 g of 1-phenyl-1-cyclopentanecarboxaldehyde oxime.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 2 h
  3. customThe solvent was evaporated in vacuo
  4. additionthe residue was treated with absolute ethanol (50 ml)
  5. filtrationthe suspension filtered
  6. customThe solvent was evaporated from the filtrate in vacuo
  7. customthe residue crystallised from a 4/1 mixture of n-heptane and ethyl acetate

出典と根拠

ORDレコード
ord-4915c322d95c4864aebbd6f6a4943ce2
出典データセット
uspto-grants-1997_03
特許番号
US05608069

反応ノート

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