Water → (1R,2S)-(+)-cis-1-Amino-2-indanol

HRID 976956

反応式

HRID 976956 の反応式
[C@@H:1]1(O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C@@H:2]1[OH:10].S(=O)(=O)(O)O.O.[OH-].[Na+].C(#[N:22])C>>[NH2:22][C@@H:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C@@H:2]1[OH:10]

参加物

6

反応物 5

HCID 962WaterHCID 1118Sulfuric AcidHCID 6342AcetonitrileHCID 14798Sodium HydroxideHCID 20758cis-1,2-Indandiol

生成物 1

HCID 2725045(1R,2S)-(+)-cis-1-Amino-2-indanol

反応条件

温度
0 °C

実験手順

Cis-1,2-indandiol (1.5 g) was dissolved in acetonitrile (25 mL) cooled to 0° C, and concentrated sulfuric acid (1.1 mL) was added. The mixture was gradually warmed to 20° C. and aged to 3 hours. Water (2 mL) was added and the mixture heated to reflux. Concentrated aqueous sodium hydroxide was added to adjust the pH to 12. The resulting solid was removed by filtration to provide an aqueous acetonitrile solution of cis-1-amino-2-indanol.

後処理

  1. temperatureThe mixture was gradually warmed to 20° C. and aged to 3 hours
  2. temperaturethe mixture heated to reflux
  3. customThe resulting solid was removed by filtration

出典と根拠

ORDレコード
ord-e75ea48617e8497492e1911921de0bc3
出典データセット
uspto-grants-1997_03
特許番号
US05612484

関連ノート

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