Hydrochloric Acid → 6-Propionyl-3-methyl thiochromane

HRID 980502

反応式

HRID 980502 の反応式
[Al+3].[Cl-].[Cl-].[Cl-].[C:5](Cl)(=[O:8])[CH2:6][CH3:7].[CH3:10][CH:11]1[CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[S:13][CH2:12]1.Cl>ClC=CCl>[C:5]([C:17]1[CH:18]=[C:19]2[C:14](=[CH:15][CH:16]=1)[S:13][CH2:12][CH:11]([CH3:10])[CH2:20]2)(=[O:8])[CH2:6][CH3:7]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 62324Propionyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 123085373-Methyl-thiochromane

生成物 1

HCID 545305286-Propionyl-3-methyl thiochromane

試薬・触媒・溶媒 1

HCID 109001,2-Dichloroethylene溶媒

実験手順

To 0.13M of AlCl3, 0.12M of propionyl chloride in 150 ml of 1,2-dichloroethylene, 0.1M (16.4 gr.) de 3-methyl-thiochromane are dropwise added at a temperature of ±5° C. After agitating the mixture for 3 hours at room temperature, a mixture of ice and HCl is added and extraction is made with CHCl3. The organic phase is dried on MgSO4, filtered and evaporated. 17.3 gr. of 6-propionyl-3-methyl thiochromane are so obtained, the homogeneity of which is verified by TLC and the structure of which is verified by NMR spectrum.

後処理

  1. additionis added
  2. extractionextraction
  3. customThe organic phase is dried on MgSO4
  4. filtrationfiltered
  5. customevaporated

出典と根拠

ORDレコード
ord-8b058bd4b3774532b9045b91d321daa0
出典データセット
uspto-grants-1987_01
特許番号
US04638070

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