Iodoethane → 5-Ethoxy-2-methylpyridine
反応式
[H-].[Na+].[OH:3][C:4]1[CH:5]=[CH:6][C:7]([CH3:10])=[N:8][CH:9]=1.[CH2:11](I)[CH3:12]>CN(C)C=O.O>[CH2:11]([O:3][C:4]1[CH:5]=[CH:6][C:7]([CH3:10])=[N:8][CH:9]=1)[CH3:12]参加物
6
実験手順
To a stirred suspension of 16.6 g sodium hydride in 500 ml dry dimethylformamide (DMF) under nitrogen at 0° C. is added 90 g 5-hydroxy-2-methylpyridine at such a rate that the temperature remains between 0°-5° C. When gas evolution ceases, 73.8 ml ethyl iodide in 100 ml DMF is added dropwise. After stirring at room temperature overnight, the mixture is diluted with water and extracted with ether. The ether extracts are washed with brine, dried and concentrated. This oil is distilled to give 62.5 g of 5-ethoxy-2-methylpyridine, bp 89°-91° C. at 12 mm.
後処理
- customremains between 0°-5° C
- extractionextracted with ether
- washThe ether extracts are washed with brine
- customdried
- concentrationconcentrated
- distillationThis oil is distilled
出典と根拠
- ORDレコード
- ord-c926faa744fc4cb8bc733a3677ac6075
- 出典データセット
- uspto-grants-1987_01
- 特許番号
- US04638068
反応ノート
読み込み中…