Succinic anhydride → 4-(3,5-Dimethyl-4-methoxyphenyl)-4-oxobutyric acid

HRID 980755

反応式

HRID 980755 の反応式
[C:1]1(=[O:7])[O:6][C:4](=[O:5])[CH2:3][CH2:2]1.[CH3:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[C:10]=1[O:16][CH3:17].[Cl-].[Cl-].[Cl-].[Al+3]>ClCCCl>[CH3:8][C:9]1[CH:14]=[C:13]([C:4](=[O:5])[CH2:3][CH2:2][C:1]([OH:6])=[O:7])[CH:12]=[C:11]([CH3:15])[C:10]=1[O:16][CH3:17]

参加物

5

反応物 3

HCID 7922Succinic anhydrideHCID 660882,6-DimethylanisoleHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 140320874-(3,5-Dimethyl-4-methoxyphenyl)-4-oxobutyric acid

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

反応条件

温度
0 °C

実験手順

Succinic anhydride (22.06 gm) was added to a mixture of 2,6-dimethylanisole (30 g) and anhydrous aluminium trichloride (59 g) in 1,2-dichloroethane (200 ml) at 0° C. The mixture was stirred for 0.5 hr at 0° C. and at room temperature for 4 hr. The mixture was poured onto ice-concentrated hydrochloric acid. After stirring vigorously for 5 min, the mixture was extracted with ethyl acetate. The dried (MgSO4) organic fraction was evaporated to give 4-(3,5-dimethyl-4-methoxyphenyl)-4-oxobutyric acid as white crystals, mp 108° C.

後処理

  1. additionThe mixture was poured onto ice-concentrated hydrochloric acid
  2. stirringAfter stirring vigorously for 5 min
  3. extractionthe mixture was extracted with ethyl acetate
  4. dry with materialThe dried (MgSO4) organic fraction
  5. customwas evaporated

出典と根拠

ORDレコード
ord-56eeba886a3c4caca4bf9402fed19c29
出典データセット
uspto-grants-1987_01
特許番号
US04639267

関連ノート

読み込み中…