Pamidronic Acid → Sodium (3-amino-1-hydroxy-1-phosphonopropyl)phosphonate

HRID 980776

反応式

HRID 980776 の反応式
[NH2:1][CH2:2][CH2:3][C:4]([OH:13])([P:9]([OH:12])(=[O:11])[OH:10])[P:5]([OH:8])(=[O:7])[OH:6].[OH-].[Na+:15]>O>[NH2:1][CH2:2][CH2:3][C:4]([OH:13])([P:5]([OH:8])(=[O:6])[OH:7])[P:9]([O-:12])(=[O:10])[O-:11].[Na+:15].[Na+:15]

参加物

4

反応物 2

HCID 4674Pamidronic AcidHCID 14798Sodium Hydroxide

生成物 1

HCID 44181920Sodium (3-amino-1-hydroxy-1-phosphonopropyl)phosphonate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

2.35 g of 3-amino-1-hydroxypropane-1,1-diphosphonic acid are suspended in 100 ml of water and, while stirring, 1N sodium hydroxide solution (approximately 20.0 ml) is added dropwise until neutralisation is complete (pH=7.4). The whole is concentrated to dryness by evaporation under reduced pressure at 60°-70° and dried under reduced pressure (approximately 20 mbar) until the weight is constant. Disodium 3-amino-1-hydroxypropane-1,1-diphosphonate is obtained in the form of an amorphous product that is deliquescent in air and that according to Karl Fischer titration contains approximately 12.9% by weight of water.

後処理

  1. concentrationThe whole is concentrated to dryness by evaporation under reduced pressure at 60°-70°
  2. customdried under reduced pressure (approximately 20 mbar) until the weight

出典と根拠

ORDレコード
ord-240d8ec3aa1a493db64bd45c3af83135
出典データセット
uspto-grants-1987_01
特許番号
US04639338

関連ノート

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