Hydrochloric Acid → 4-(Ethyl(2-hydroxyethyl)amino)benzaldehyde

HRID 983575

反応式

HRID 983575 の反応式
[OH-].[Na+].[CH2:3]([N:5]([CH2:14][CH2:15][O:16]C(=O)C)[C:6]1[CH:11]=[CH:10][C:9]([CH:12]=[O:13])=[CH:8][CH:7]=1)[CH3:4].Cl>C(O)C>[CH2:3]([N:5]([C:6]1[CH:7]=[CH:8][C:9]([CH:12]=[O:13])=[CH:10][CH:11]=1)[CH2:14][CH2:15][OH:16])[CH3:4]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 11458991Benzaldehyde, 4-[[2-(acetyloxy)ethyl]ethylamino]-

生成物 1

HCID 6398574-(Ethyl(2-hydroxyethyl)amino)benzaldehyde

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
40 °C

実験手順

A 150 ml of NaOH-solution (5 M in water) is added to a solution of 59.2 g (252 mmol) of 17 in 200 ml of ethanol and the mixture is stirred overnight at 40° C. The reaction mixture is cooled in an ice bath and neutralized with HCl (5 M) and extracted with dichloromethane. The organic layer is washed with a saturated NaHCO3-solution, with brine and dried over MgSO4. The solvents are evaporated under reduced pressure. The product is isolated as an oil and used without further purification.

後処理

  1. temperatureThe reaction mixture is cooled in an ice bath
  2. extractionextracted with dichloromethane
  3. washThe organic layer is washed with a saturated NaHCO3-solution, with brine
  4. dry with materialdried over MgSO4
  5. customThe solvents are evaporated under reduced pressure
  6. customThe product is isolated as an oil
  7. customused without further purification

出典と根拠

ORDレコード
ord-067bfc77490a46de92e6cddc0813553f
出典データセット
uspto-grants-2005_03
特許番号
US06864347B2

関連ノート

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