1-Methylpiperazine → 5-Chloro-7-methyl-2-(4-methyl-1-piperazinyl)benzoxazole

HRID 984085ノート

反応式

HRID 984085 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH3:12])[C:5]2[O:9][C:8](S)=[N:7][C:6]=2[CH:11]=1.[CH3:13][N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH3:12])[C:5]2[O:9][C:8]([N:17]3[CH2:18][CH2:19][N:14]([CH3:13])[CH2:15][CH2:16]3)=[N:7][C:6]=2[CH:11]=1

参加物

4

反応物 2

HCID 531671-MethylpiperazineHCID 178426087HCID 178426087、化合物

生成物 1

HCID 106117595-Chloro-7-methyl-2-(4-methyl-1-piperazinyl)benzoxazole

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

5-Chloro-7-methyl-2-mercaptobenzoxazole (200 mg) was dissolved in chloroform (20 ml), N-methylpiperazine (0.55 ml) was added dropwise to the solution and then the mixture was stirred with heating for 3 days. After evaporation of the solvent, the thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=20:1) to obtain the title compound 5-chloro-7-methyl-2-(4-methyl-1-piperazinyl)benzoxazole (270 mg).

後処理

  1. temperaturewith heating for 3 days
  2. customAfter evaporation of the solvent
  3. customthe thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=20:1)

出典と根拠

ORDレコード
ord-205b9f70bf53486eb4c9951648a41584
出典データセット
uspto-grants-2005_03
特許番号
US06867226B2

反応ノート

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