反応式
C1C=CC([C:7]2[CH:8]=[CH:9][C:10]([CH:13]([N:20]3[CH:24]=[N:23][CH:22]=[CH:21]3)C3C=CC=CC=3)=[CH:11][CH:12]=2)=CC=1.N1C=CN=C1.C1(C(Cl)=[O:37])C=CC=CC=1>>[C:13]([N:20]1[CH:21]=[CH:22][N:23]=[CH:24]1)(=[O:37])[C:10]1[CH:9]=[CH:8][CH:7]=[CH:12][CH:11]=1参加物
4
実験手順
Bifonazole has also been prepared by benzoylation of imidazole with PhCOCl, yielding 74.7% of 1-benzoylimidazole which is subject to react with Gringnard's reactant 4-PhC6H4MgBr followed by a tosylation and subsequent reduction with sodium cyanoborohydride in hexamethylphosphoramide, to yield 68.2% Bifonazole (Es. Patent 539,345).
出典と根拠
- ORDレコード
- ord-1b8366f4615041a388dd5cce112ded97
- 出典データセット
- uspto-grants-2005_03
- 特許番号
- US06870057B1
関連ノート
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