Imidazole → 1-(5-Nitro-2-methyl-phenylsulfonyl)-imidazole

HRID 985957

反応式

HRID 985957 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH3:14])=[C:8]([S:10](Cl)(=[O:12])=[O:11])[CH:9]=1)([O-:3])=[O:2].[NH:15]1[CH:19]=[CH:18][N:17]=[CH:16]1.O>N1C=CC=CC=1>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH3:14])=[C:8]([S:10]([N:15]2[CH:19]=[CH:18][N:17]=[CH:16]2)(=[O:12])=[O:11])[CH:9]=1)([O-:3])=[O:2]

参加物

5

反応物 3

HCID 795ImidazoleHCID 962WaterHCID 8457o-Toluenesulfonyl chloride, 5-nitro-

生成物 1

HCID 6850571-(5-Nitro-2-methyl-phenylsulfonyl)-imidazole収率 63.6%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
50 °C

実験手順

2.36 g of 5-nitro-2-methyl-phenylsulfonyl chloride (0.01 mol) and 1.36 g of imidazole (0.02 mol) were dissolved in 15 ml of pyridine, and the mixture was stirred at 50° C. for 3 hours to react. After the reaction, the reaction mixture was poured into water, and extracted with chloroform. The chloroform layer was washed with water and dehydrated. Evaporation of chloroform gave 1.70 g of 1-(5-nitro-2-methyl-phenylsulfonyl)-imidazole of the m.p. 119°-120° C.

後処理

  1. customto react
  2. customAfter the reaction
  3. extractionextracted with chloroform
  4. washThe chloroform layer was washed with water
  5. customEvaporation of chloroform

出典と根拠

ORDレコード
ord-fcb44b4c21584b2e92d076268a6bba5c
出典データセット
uspto-grants-1987_12
特許番号
US04710509

関連ノート

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