Water → HCID 14032941、化合物

HRID 986387ノート

反応式

HRID 986387 の反応式
[CH3:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][N:5]2[C:11]=1[C:12]([NH:14][NH2:15])=[O:13].C(N(CC)CC)C.[Cl:23][CH2:24][C:25](Cl)=[O:26].O>C(Cl)(Cl)Cl>[Cl:23][CH2:24][C:25]([NH:15][NH:14][C:12]([C:11]1[N:5]2[CH:6]=[C:7]([CH3:10])[CH:8]=[CH:9][C:4]2=[N:3][C:2]=1[CH3:1])=[O:13])=[O:26]

参加物

6

反応物 4

HCID 962WaterHCID 6577Chloroacetyl chlorideHCID 8471TriethylamineHCID 20157442HCID 20157442、化合物

生成物 1

HCID 14032941HCID 14032941、化合物収率 105.6%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

To a mixture of 14.8 g of 2,6-dimethylimidazo[1,2-a]pyridine-3-carbohydrazide and 7.36 g of triethylamine in 300 ml of chloroform with stirring under cooling is added dropwise a solution of 8 g of chloroacetyl chloride in 50 ml of chloroform at 5°-10° C. After the mixture is stirred for 30 minutes, the reaction temperature is raised to room temperature and the resultant mixture is further stirred for 30 minutes. To the reaction mixture is added water and the precipitated crystals are collected by filtration to give 21 g of N'-chloroacetyl-2,6-dimethylimidazo[1,2-a]pyridine-3-carbohydrazide, melting at 290°-291° C. with decomposition.

後処理

  1. temperatureunder cooling
  2. stirringAfter the mixture is stirred for 30 minutes
  3. filtrationthe precipitated crystals are collected by filtration

出典と根拠

ORDレコード
ord-94a175f3cb80439ab86365f7a7d91fdb
出典データセット
uspto-grants-1987_12
特許番号
US04713381

反応ノート

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