Sodium Hydroxide → 7-Thienylamino-1H-pyrazolo[4,3-b]pyridine

HRID 986746

反応式

HRID 986746 の反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[NH:6][C:7]1[C:12](C(OCC)=O)=[CH:11][N:10]=[C:9]2[CH:18]=[N:19][NH:20][C:8]=12.[OH-].[Na+]>C(O)C>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]2[CH:18]=[N:19][NH:20][C:8]=12

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 20156241Ethyl 7-thienylamino-1H-pyrazolo[4,3-b]pyridine-6-carboxylate

生成物 1

HCID 201562447-Thienylamino-1H-pyrazolo[4,3-b]pyridine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Ethyl 7-thienylamino-1H-pyrazolo[4,3-b]pyridine-6-carboxylate (0.600 g) was converted to the corresponding acid by heating under reflux with a 2% sodium hydroxide solution in ethanol (50 ml). The ethanol was removed under reduced pressure and the residue diluted with water (5 ml) and acidified to pH5 with dilute hydrochloric acid. The resulting acid was filtered off and dried, mp 255°-259° C.

後処理

  1. temperatureby heating
  2. customThe ethanol was removed under reduced pressure
  3. additionthe residue diluted with water (5 ml)
  4. filtrationThe resulting acid was filtered off
  5. customdried

出典と根拠

ORDレコード
ord-795da91dd8ec4d3bba0d28a4380803d5
出典データセット
uspto-grants-1987_12
特許番号
US04716160

関連ノート

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