Lithium Hydroxide → 2-Isopropoxy-3-[4-(2-{4-methylsulfonyloxyphenyl}ethoxy)phenyl]propanoic acid

HRID 987340ノート

反応式

HRID 987340 の反応式
C[O:2][C:3](=[O:30])[CH:4]([O:26][CH:27]([CH3:29])[CH3:28])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][S:22]([CH3:25])(=[O:24])=[O:23])=[CH:17][CH:16]=2)=[CH:8][CH:7]=1.[OH-].[Li+]>O1CCCC1.O>[CH:27]([O:26][CH:4]([CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH2:14][C:15]2[CH:16]=[CH:17][C:18]([O:21][S:22]([CH3:25])(=[O:24])=[O:23])=[CH:19][CH:20]=2)=[CH:8][CH:7]=1)[C:3]([OH:30])=[O:2])([CH3:28])[CH3:29]

参加物

5

反応物 2

HCID 3939Lithium HydroxideHCID 572273272-Isopropoxy-3-[4-(2-{4-methylsulfonyloxyphenyl}ethoxy)phenyl]propanoic acid methyl ester

生成物 1

HCID 229887122-Isopropoxy-3-[4-(2-{4-methylsulfonyloxyphenyl}ethoxy)phenyl]propanoic acid収率 88%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

2-Isopropoxy-3-[4-(2-{4-methylsulfonyloxyphenyl}ethoxy)phenyl]propanoic acid methyl ester (0.1 g; 0.229 mmole) was dissolved in tetrahydrofuran(2 ml). Lithium hydroxide (0.006 g; 0.25 mmole) in water (2 ml) was added. The reaction mixture was stirred at room temperature for 8 hours. Tetrahydrofuran was evaporated. The remaining water solution was extracted with diethyl ether. The water solution was then acidified with hydorchloric acid (1%) to pH˜2 and extracted twice with ethyl acetate. The organic phases were combined and dried with magnesium sulfate. The solvent was evaporated and 0.085 g (88% yield) of 2-isopropoxy-3-[4-(2-{4-methylsulfonyloxyphenyl}ethoxy)phenyl]propanoic acid was obtained.

後処理

  1. customTetrahydrofuran was evaporated
  2. extractionThe remaining water solution was extracted with diethyl ether
  3. extractionextracted twice with ethyl acetate
  4. dry with materialdried with magnesium sulfate
  5. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-ae5fbe511fc240fa97b44b1194588fba
出典データセット
uspto-grants-2003_10
特許番号
US06630600B1

反応ノート

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