2-Methyl-1-butanol → N-(phenylacetyl)valine 2-methylbutyl Ester

HRID 987808

反応式

HRID 987808 の反応式
[C:1]1([CH2:7][C:8]([NH:10][C@H:11]([C:15]([OH:17])=[O:16])[CH:12]([CH3:14])[CH3:13])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:18][CH:19]([CH2:22][CH3:23])[CH2:20]O>>[CH3:18][CH:19]([CH2:22][CH3:23])[CH2:20][O:16][C:15](=[O:17])[C@H:11]([CH:12]([CH3:13])[CH3:14])[NH:10][C:8](=[O:9])[CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

3

反応物 2

HCID 87232-Methyl-1-butanolHCID 853958(2S)-3-methyl-2-(2-phenylacetamido)butanoic acid

生成物 1

HCID 15481773N-(phenylacetyl)valine 2-methylbutyl Ester

実験手順

Following General Procedure BC and using the N-(phenylacetyl)valine prepared in Step A above and 2-methylbutan-1-ol (Aldrich), the title compound was prepared as a diastereomeric mixture. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

後処理

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

出典と根拠

ORDレコード
ord-dd4e96332c8d4cb1a1d13b9d3530f049
出典データセット
uspto-grants-2003_10
特許番号
US06632811B2

関連ノート

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