2-(4-Benzyloxy-3-propoxyphenyl)-5,5-dimethyl-1,3-dioxane → HCID 22987076、化合物

HRID 987869ノート

反応式

HRID 987869 の反応式
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]2[O:20][CH2:19][C:18]([CH3:22])([CH3:21])[CH2:17][O:16]2)=[CH:11][C:10]=1[O:23][CH2:24][CH2:25][CH3:26])C1C=CC=CC=1>[Pd].O1CCCC1>[CH3:21][C:18]1([CH3:22])[CH2:17][O:16][CH:15]([C:12]2[CH:13]=[CH:14][C:9]([OH:8])=[C:10]([O:23][CH2:24][CH2:25][CH3:26])[CH:11]=2)[O:20][CH2:19]1

参加物

4

反応物 1

HCID 229870842-(4-Benzyloxy-3-propoxyphenyl)-5,5-dimethyl-1,3-dioxane

生成物 1

HCID 22987076HCID 22987076、化合物収率 98.9%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 1.07 g (3.00 mmol) of 2-(4-benzyloxy-3-propoxyphenyl)-5,5-dimethyl-1,3-dioxane, 15 ml of tetrahydrofuran and 107 g of 10% palladium/C hydrogenation catalyst was hydrogenated at room temperature. After the absorption of 62.4 ml of hydrogen, the reaction suspension was filtered through Dicalite and evaporated down. Chromatography of the residue over 25 g of silica gel using 19:1 toluene/ethyl acetate gave 790 mg of 4-(5,5-dimethyl-1,3-dioxan-2-yl)-2-propoxyphenol.

後処理

  1. customwas hydrogenated at room temperature
  2. customAfter the absorption of 62.4 ml of hydrogen
  3. filtrationthe reaction suspension was filtered through Dicalite
  4. customevaporated down

出典と根拠

ORDレコード
ord-a94e7249634744398b4e399e10a46b1a
出典データセット
uspto-grants-2003_10
特許番号
US06632909B2

反応ノート

読み込み中…