4-Chlorobutyronitrile → HCID 178478461、化合物

HRID 988240ノート

反応式

HRID 988240 の反応式
[Cl:1][CH2:2][CH2:3][CH2:4][C:5]#[N:6].[N-:7]=[N+:8]=[N-:9].[Na+].[Cl-].[NH4+].[OH-].[Na+]>CN(C)C=O>[Cl:1][CH2:2][CH2:3][CH2:4][C:5]1[NH:9][N:8]=[N:7][N:6]=1

参加物

6

反応物 4

HCID 123364-ChlorobutyronitrileHCID 14798Sodium HydroxideHCID 25517Ammonium ChlorideHCID 33557Sodium Azide

生成物 1

HCID 178478461HCID 178478461、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
140 °C

実験手順

A mixture of 3.5 g of 4-chlorobutyronitrile, 2.3 g of sodium azide and 1.9 g of ammonium chloride in 50 ml of dimethyl-formamide is stirred at 140° C. for 20 hours. The reaction mixture is poured onto ice, basified with 1N sodium hydroxide and extracted twice with ethyl acetate. The aqueous fraction is acidified with acetic acid and extracted with ethylacetate. Evaporation of the ethyl acetate gives 5-(3-chloropropyl)-tetrazole, which is used directly in the next step.

後処理

  1. additionThe reaction mixture is poured onto ice
  2. extractionextracted twice with ethyl acetate
  3. extractionextracted with ethylacetate
  4. customEvaporation of the ethyl acetate

出典と根拠

ORDレコード
ord-6667e7b5504e42b9bc80d0351e0efbeb
出典データセット
uspto-grants-2003_10
特許番号
US06635655B1

反応ノート

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