1-(Methylsulfonyl)-4-nitrobenzene → 4-(Methylsulfonyl)aniline

HRID 988670ノート

反応式

HRID 988670 の反応式
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][CH:6]=1)(=[O:4])=[O:3]>C1COCC1.C(O)C.[Pd]>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)(=[O:3])=[O:4]

参加物

5

反応物 1

HCID 2584341-(Methylsulfonyl)-4-nitrobenzene

生成物 1

HCID 796174-(Methylsulfonyl)aniline収率 91%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 702Ethanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 4-(methylsulfonyl)nitrobenzene (6.26 g, 31.1 mmol) in THF (200 mL) and ethanol (100 mL) was placed in a high pressure reaction vessel and to this solution was added 5% Pd/C (1.6 g). The vessel was shaken for 8 h under an atmosphere of hydrogen (60 psi). The solution was then filtered through diatomaceous earth, partially concentrated in vacuo, and diluted with diethyl ether. The resulting precipitate was filtered and dried in vacuo to give 4.84 g (91%) of a tan solid.

後処理

  1. filtrationThe solution was then filtered through diatomaceous earth
  2. concentrationpartially concentrated in vacuo
  3. additiondiluted with diethyl ether
  4. filtrationThe resulting precipitate was filtered
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-00c24e1160a44ca8bc213f8b83268465
出典データセット
uspto-grants-2003_10
特許番号
US06635657B1

反応ノート

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