Hydrogen Sulfide → Ethyl thiazole-4-carboxylate

HRID 990881ノート

反応式

HRID 990881 の反応式
[CH2:1]([O:3][C:4](=[O:12])[C:5]([N+:10]#[C-:11])=[CH:6]N(C)C)[CH3:2].C(N(CC)CC)C.[SH2:20]>O1CCCC1>[C:4]([C:5]1[N:10]=[CH:11][S:20][CH:6]=1)([O:3][CH2:1][CH3:2])=[O:12]

参加物

5

反応物 3

HCID 402Hydrogen SulfideHCID 8471TriethylamineHCID 54355309Ethyl 3-(dimethylamino)-2-isocyanoacrylate

生成物 1

HCID 5003096Ethyl thiazole-4-carboxylate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 3-dimethylamino-2-isocyano-acrylic acid ethyl ester (1.0 g) and triethylamine (3.0 g) in tetrahydrofuran (30 mL) is treated with gaseous hydrogen sulfide until all starting material is consumed. The mixture is concentrated to an oil and purified by column chromatography using silica and 25% ethyl acetate-hexanes as the eluant. The purified material (0.61 g) is isolated as an oil.

後処理

  1. customis consumed
  2. concentrationThe mixture is concentrated to an oil
  3. custompurified by column chromatography

出典と根拠

ORDレコード
ord-3407dc415234491da45c7e02559055dc
出典データセット
uspto-grants-2002_10
特許番号
US06462055B2

反応ノート

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