Lithium Hydroxide → 2-(4-Chlorophenyl)-2-hydroxypropanoic acid
反応式
C([O:3][C:4](=[O:15])[C:5]([C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1)([OH:7])[CH3:6])C.[OH-].[Li+]>O1CCCC1.O>[Cl:14][C:11]1[CH:10]=[CH:9][C:8]([C:5]([OH:7])([CH3:6])[C:4]([OH:15])=[O:3])=[CH:13][CH:12]=1参加物
5
実験手順
A solution of 5.72 g of the 2-(4-chlorophenyl)-2-hydroxy propionic acid ethyl ester in 170 ml tetrahydrofurane is hydroysed at 0° C. with a solution of 30.5 ml 1N lithiumhydroxide in 19 ml water. When the reaction is complete, the reaction mixture is diluted with water, washed with diethyl ether, acidified with 1N HCl and extracted with ethyl acetate. The extracts are washed with brine, dried over sodium sulfate and evaporated to give 2-(4-chlorophenyl)-2-hydroxy propionic acid.
後処理
- washwashed with diethyl ether
- extractionextracted with ethyl acetate
- washThe extracts are washed with brine
- dry with materialdried over sodium sulfate
- customevaporated
出典と根拠
- ORDレコード
- ord-66ebd3e304814a6a93b3c2cd8d8d5741
- 出典データセット
- uspto-grants-2002_10
- 特許番号
- US06469005B1
反応ノート
読み込み中…